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How reproducible are real-world research utilizing medical observe knowledge? – Healthcare Economist


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That’s the query posed by a paper by Wang, Sreedhara and Schneeweiss (2022). The authors replicate the findings from n=250 real-world knowledge research. The research have been replicated utilizing 3 datasets: (i) Optum Clinformatics claims knowledge, (ii) IBM MarketScan Analysis Database claims knowledge, Medicare fee-for-service claims knowledge, and (iii) CPRD digital well being data. Key paper findings are beneath:

Unique and copy impact sizes have been positively correlated (Pearson’s correlation = 0.85), a powerful relationship with some room for enchancment. The median and interquartile vary for the relative magnitude of impact (e.g., hazard ratiooriginal/ hazard ratioreproduction) is 1.0 [0.9, 1.1], vary [0.3, 2.1]. Whereas the vast majority of outcomes are intently reproduced, a subset will not be. The latter will be defined by incomplete reporting and up to date knowledge. Higher methodological transparency aligned with new steering could additional enhance reproducibility and validity evaluation, thus facilitating evidence-based decision-making


This paper received the 2023 Award for Excellence in Well being Economics and Outcomes Analysis Methodology. You possibly can learn the total paper right here.

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